10 March 2025 Football

Champions League betting tips: Round of 16 second leg previews

Written by: Alex Harris Football Tipster
7 min to read
IMAGO Antoine Griezmann could be vital if Atletico are to turn around the first leg deficit against Real Madrid
IMAGO Antoine Griezmann could be vital if Atletico are to turn around the first leg deficit against Real Madrid

Barcelona vs Benfica betting tips 

Barcelona recovered from Pau Cubarsi's red card to win the first leg 1-0 thanks to Raphinha's sublime strike. 

It was their second victory over Benfica this season - adding to a league-phase success - and they should have the psychological edge to make it three. 

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Barcelona have hit 14 goals in four Champions League home games and, despite boasting a mean defensive record on the road, the Portuguese outfit could be overwhelmed. 

Robert Lewandowski bagged a brace in January's meeting and will fancy his chances of adding to his 34-goal tally for the campaign. 

Score prediction 

Barcelona 3-1 Benfica (8/1 with Betway)

FIRST's top tip

Robert Lewandowski anytime goalscorer (83/100 with Mr.Play)

Inter Milan vs Feyenoord betting tips 

First-leg goals from Marcus Thuram and Lautaro Martinez means Inter Milan are in the driving seat.

It was an eighth clean sheet in nine Champions League games for Simone Inzaghi's side and they should punch their ticket to the quarter-finals as Feyenoord have won only one of their last eight away games.

A further worry for the Dutch outfit is that Inter have lost just once on home soil in all tournaments this season - and that came against arch-rivals and fellow San Siro residents AC Milan!

Sure, Feyenoord claimed a draw on their last trip to the stadium when knocking out Milan, but the Nerazzurri are a better team.

The hosts will take a professional approach to seeing through the job.

Score prediction 

Inter Milan 1-0 Feyenoord (6/1 with Betway)

FIRST's top tip

Inter Milan to win & both teams to score - No (23/20 with Betway)

Liverpool vs PSG betting tips 

Liverpool might have been facing an early elimination if it wasn't for Alisson's first-leg heroics.

PSG had chances but failed to beat the Brazilian and their pressure counted for nothing as Harvey Elliott fired a late winner to give the Reds the lead. 

Arne Slot's side boast a perfect record at Anfield in this season's Champions League and will surely create more chances than they did in Paris.  

You would expect PSG to go full throttle as they attempt to overturn the one-goal deficit, but they were beaten at Arsenal and Bayern Munich in the league phase and old weaknesses could re-emerge.

While we have full Liverpool vs PSG betting tips to sink your teeth into. In a nutshell, the first goal will be critical - something Liverpool have achieved in their last eight Champions League games. 

Score prediction 

Liverpool 2-1 PSG (8/1 with Betway)

FIRST's top tip

Liverpool first goal (5/6 with Betway)

Bayer Leverkusen vs Bayern Munich betting tips 

The all-German scrap failed to live up to expectations as Bayern Munich cruised to a 3-0 victory last Wednesday.  

It abruptly ended Bayer Leverkusen's unbeaten streak against their rivals and, instead, made it two meetings in a row without netting. 

A spark of hope for Xabi Alonso's team is that Bayern have lost three of their five away games in the Champions League and an early goal could make things interesting. But star midfield man Florian Wirtz is a potential absentee after limping out of Saturday's Bundesliga defeat to Werder Bremen. 

The hosts will need to play on the front foot and might be vulnerable in transitions, which would play out perfectly for Michael Olise to shine and add to his five Champions League goals.  

Score prediction 

Bayer Leverkusen 1-1 Bayern Munich (11/2 with Betway)

FIRST's top tip

Michael Olise anytime goalscorer (71/20 with Mr.Play)

Lille vs Borussia Dortmund betting tips 

Wednesday's slate begins with an evenly-poised tie after Borussia Dortmund and Lille's first leg finished 1-1.

The outcome was not surprising as the teams were separated by a point in the league table, but it was far from a classic as they managed just one shot on target each. 

With both clubs failing to live up to expectations domestically, they will be eager to continue their European journeys, and chances could be at a premium again. 

Dortmund have Champions League top scorer Serhou Guirassy in their ranks and he could be the man to settle proceedings. 

Score prediction 

Lille 0-1 Borussia Dortmund (15/2 with Betway)

FIRST's top tip

Serhou Guirassy anytime goalscorer (183/100 with Mr.Play)

Aston Villa vs Club Brugge betting tips 

Aston Villa have one foot in the quarter-finals after last week's 3-1 win, but Unai Emery will ensure complacency doesn't creep in. 

The Spaniard has moulded Villa into a street-wise outfit in Europe, and they should be able to manage the situation against the lowest-ranked team from the league phase still involved.  

Club Brugge need to score twice without conceding to take the tie to extra time - and that is something they have achieved just twice in 11 Champions League games. 

There have been two goals or fewer in three of Villa's four home games, and another low-scoring affair could be on the cards. 

Score prediction 

Aston Villa 1-1 Club Brugge (7/1 with Betway)

FIRST's top tip

Under 2.5 goals (13/10 with Betway)

Arsenal vs PSV betting tips 

We move on to what is effectively a dead-rubber after Arsenal spanked PSV 7-1 in the first leg.  

The Gunners suddenly found their shooting boots, but that was hardly surprising as the Dutch outfit's defensive record leaves you feeling cold, having conceded 36 goals in their last 15 games. 

We might see much-changed teams taking to the pitch as Mikel Arteta will want to give a breather to some and Peter Bosz would be wise to switch attention to the Eredivisie title race. 

Score prediction 

Arsenal 1-1 PSV (15/2 with Betway)

FIRST's top tip

Match winner & both teams to score - Draw & yes (5/1 with Betway)

Atletico Madrid vs Real Madrid betting tips

Diego Simeone has failed to guide Atletico Madrid to victory against Real Madrid in six previous Champions League meetings. 

Wednesday's tie would be the perfect time to scratch that itch because they must beat their city rivals, or they will be out. 

It's been a bad week for Atletico as last Tuesday's 2-1 loss to Real was followed by a dramatic defeat to Getafe on Saturday - and it could get worse as the flow of Wednesday's clash is likely to favour the visitors. 

Carlo Ancelotti's team are perfectly suited to European occasions when it's backs against the wall. 

They will soak up pressure and should be able to hit the hosts on the break to grab the goal that might be enough to get them over the line.

A close result is to be expected as the previous three meetings before last week's match ended 1-1. 

Score prediction 

Atletico Madrid 1-1 Real Madrid (11/2 with Betway)

FIRST's top tip

Double chance & both teams to score - Draw or Real Madrid & yes (5/4 with Betway)

Odds correct at the time of writing.

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